Transcriptome-wide association study of inflammatory biologic age
نویسندگان
چکیده
منابع مشابه
Transcriptome-wide association study of inflammatory biologic age
Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the Klemera-Doubal method to estimate inflamma...
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PURPOSE To determine if plasma metabolic profiles can detect differences between patients with neovascular age-related macular degeneration (NVAMD) and similarly-aged controls. METHODS Metabolomic analysis using liquid chromatography with Fourier-transform mass spectrometry (LC-FTMS) was performed on plasma samples from 26 NVAMD patients and 19 controls. Data were collected from mass/charge r...
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1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. 2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 3David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. 4Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Mass...
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The past decade has seen a rapid growth in omics technologies. Genome-wide association studies (GWAS) have uncovered susceptibility variants for a variety of complex traits. However, the functional significance of most discovered variants are still not fully understood. On the other hand, there is increasing interest in exploring the role of epigenetic variations such as DNA methylation in dise...
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BACKGROUND Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children. OBJECTIVE We sought to identify genetic variants associated with earlier onset of childhood asthma. METHODS We conducted the first ...
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ژورنال
عنوان ژورنال: Aging
سال: 2017
ISSN: 1945-4589
DOI: 10.18632/aging.101321